I either go with melee/flashbang build with transfusion. Transfusion now activates on shoulder charge. Spec the immediate chance for melee cooldown too, but super energy on melee kill is nice too. I just use Inmost Light with this one, but I guess Insurmountable Skull would be a better one. Throw a flashbang and then storm into the room, shoulder charge the first one in there then use combination of melee and shotty to clean up the rest. Go for a fast-firing one like Invective or the crucible shotgun.
Or I go for lightning grenades, pulse charge on super and increased pulse/lightning duration. Wear Armamentarium and you can shut down two entries to an area this way. Great control. I have more success with the latter, but really dig the in your face style of my flashbang/melee/shotgun build.